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Image Search Results
Journal: bioRxiv
Article Title: Heterozygous deletion of SYNGAP enzymatic domains in rats causes selective learning, social and seizure phenotypes
doi: 10.1101/2020.10.14.339192
Figure Lengend Snippet: (A) Schematic of the 3 chamber tasks. In the social interaction task, time in chamber (B) and sociability index (C) indicate WT and Syngap +/Δ-GAP rats show a preference for spending time in the chamber containing a caged social stimulus compared to the chamber containing an empty wire cage. (D) Time actively exploring (sniffing) and (E) sociability index for active exploration suggest that both WT and Syngap +/Δ-GAP littermates explore the social stimulus more (n +/+ = 12, n +/Δ-GAP = 14). In the social preference task, time in chamber (F) and social preference index (G) indicate WT and Syngap +/Δ-GAP rats spend significantly more time in the chamber containing a caged social stimulus compared to the chamber containing a novel object. However, Syngap +/Δ-GAP rats do not show preference for actively exploring the social stimulus over the object (H-I) (n +/+ = 10, n +/Δ-GAP = 10). Diamonds illustrate above chance performance ( p <0.05). See also for results during the novelty phase of the tasks, i.e the first 3 min.
Article Snippet: Performance was indistinguishable between
Techniques:
Journal: bioRxiv
Article Title: Heterozygous deletion of SYNGAP enzymatic domains in rats causes selective learning, social and seizure phenotypes
doi: 10.1101/2020.10.14.339192
Figure Lengend Snippet: (A) Schematic illustration of spontaneous exploration tasks for object (OR), object-context (OCR), object-place (OPR) and object-place-context (OPCR) novelty recognition. (B) Syngap +/Δ-GAP rats spend less time exploring during the first exposure of the objects in different configurations. (C) Both WT and Syngap +/Δ-GAP rats that reach exploration criterion (see methods) exhibit short term memory for all four tasks, as measured by above chance performance (illustrated by diamonds for p <0.05). In the marble burying task, Syngap +/Δ-GAP rats (D) spent significantly less time interacting with marbles and (E) their interactions were less frequent compared to WT littermates. mean ± SE is noted.
Article Snippet: Performance was indistinguishable between
Techniques: